01
Contributed to PLGA-PCL microsphere systems delivering EphA2-targeted prodigiosin and paclitaxel to eliminate residual triple-negative breast tumors after resection in preclinical models.
Project 03Collaborative Translational Research
Collaborative Development of Targeted Cancer Therapies
Collaborated on targeted, sustained-release therapies that pair biomaterials with receptor-specific drug delivery to treat cancer locally, reduce off-target exposure, and help prevent recurrence after tumor resection.
The problem
How can a therapy concentrate its effect at the tumor site while reducing systemic toxicity and the risk of local recurrence?
Approach
Designed and characterized targeted drug-conjugate, nanoparticle, microsphere, and magnetite-modified PDMS systems; then evaluated release kinetics, thermal behavior, cancer-cell response, and therapeutic relevance.
Outcome
Contributed to peer-reviewed evidence for localized, receptor-targeted drug delivery and externally triggered hyperthermia across triple-negative breast and prostate cancer applications.
What I led and delivered
02
Supported receptor-targeted PDMS and magnetite-enabled drug-delivery systems with sustained release, apoptosis assessment, and hyperthermia potential.
03
Applied release kinetics, thermodynamics, cell-viability, and materials characterization to establish how formulation design shapes therapeutic effect.
Research underpinning this work
2023
Journal of Materials Science: Materials in Medicine
Targeted drug-loaded PLGA-PCL microspheres for specific and localized treatment of triple negative breast cancer
2024
Journal of Functional Biomaterials
Luteinizing Hormone-Releasing Hormone (LHRH)-Conjugated Cancer Drug Delivery from Magnetite Nanoparticle-Modified Microporous Poly-Di-Methyl-Siloxane (PDMS) Systems for the Targeted Treatment of Triple Negative Breast Cancer Cells
2022
Journal of Biomedical Materials Research Part B
Sustained release of alpha-methylacyl-CoA racemase (AMACR) antibody-conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition
2023
Journal of Biomedical Materials Research Part B
Laser-induced heating of polydimethylsiloxane-magnetite nanocomposites for hyperthermic inhibition of triple-negative breast cancer cell proliferation
2022
Journal of Applied Polymer Science
Mechanical and thermal properties of polydimethylsiloxane/magnetite nanocomposites for cancer treatment by localized hyperthermia and photothermal ablation
Demonstrates
Targeted therapies · biomaterials innovation · translational cancer research